File:The genetics of early optic vesicle development.png
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| Description | Figure 3. The genetics of optic cup and lens formation. (a) A preplacodal region develops within the surface ectoderm overlying the optic pit/groove, stimulated by expression of SIX3, which activates PAX6 and SOX2. (b) The lens placode is signalled to thicken through LHX2-regulated BMP4 expression from the evaginating optic vesicle. (c) The developing lens placode releases BMP and retinoic acid (RA), which bind to the optic vesicle, stimulating coordinated invagination of the optic vesicle and lens placode, which forms the lens pit. (d) The invagination of the optic vesicle results in the formation of a bilayered optic cup. (e) TGFβ signalling from the extraocular mesenchyme induces and maintains MITF and OTX2 expression in the outer layer of the optic cup, which forms the presumptive retinal pigmented epithelium (RPE). FGF signals from the surface ectoderm stimulate the inner layer of the optic cup to form a VSX2-expressing presumptive neural retina (NR). The continued invagination of the lens pit results in the formation of the lens vesicle. (f) From 47 days gestation, retinal differentiation occurs, with the inner layer of the optic cup forming the neural retina (NR) and the outer layer forming the retinal pigmented epithelium (RPE). The lens vesicle detaches from the surface ectoderm and forms a definitive lens by 58 days gestation |
| Date | |
| Source | https://www.mdpi.com/2221-3759/7/3/16 Harding, P.; Moosajee, M. The Molecular Basis of Human Anophthalmia and Microphthalmia. J. Dev. Biol. 2019, 7, 16. https://doi.org/10.3390/jdb7030016 |
| Author | Harding, P.; Moosajee, M. |
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https://www.mdpi.com/2221-3759/7/3/16 Harding, P.; Moosajee, M. The Molecular Basis of Human Anophthalmia and Microphthalmia. J. Dev. Biol. 2019, 7, 16. https://doi.org/10.3390/jdb7030016, was reviewed on 13 October 2024 by reviewer Metacladistics, who confirmed that it was available there under the stated license on that date.
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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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| current | 20:17, 12 September 2024 | | 3,220 × 1,808 (875 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 3. The genetics of optic cup and lens formation. (a) A preplacodal region develops within the surface ectoderm overlying the optic pit/groove, stimulated by expression of SIX3, which activates PAX6 and SOX2. (b) The lens placode is signalled to thicken through LHX2-regulated BMP4 expression from the evaginating optic vesicle. (c) The developing lens placode releases BMP and retinoic acid (RA), which bind to the optic vesicle, stimulating coordinated invaginat... |
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