File:Free-Fatty-Acid-Induced-PP2A-Hyperactivity-Selectively-Impairs-Hepatic-Insulin-Action-on-Glucose-pone.0027424.g002.jpg

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English: □ Control; ▪ 0.5 mM Palmitate. (a) Insulin-suppression of G6pc mRNA was significantly inhibited in hepatocytes treated for 20 h with palmitate in vitro. This suppression was not affected by preincubation with 20 µM of a pseudosubstrate inhibitor of the aPKCs (Inh). (b) On the other hand, insulin-stimulated induction of Srebp1c mRNA was maintained in palmitate-treated cells. Induction could, however, be inhibited by addition of the aPKC inhibitor (Inh). Relative expression is relative to no insulin. Data are averages of real-time PCR results +/− std. error of the mean, n = 10. * indicates p<0.05 between groups.
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Source Image file from Galbo T, Olsen G, Quistorff B, Nishimura E (2011). "Free Fatty Acid-Induced PP2A Hyperactivity Selectively Impairs Hepatic Insulin Action on Glucose Metabolism". PLOS ONE. DOI:10.1371/journal.pone.0027424. PMID 22087313. PMC: 3210172.
Author Galbo T, Olsen G, Quistorff B, Nishimura E
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current22:42, 7 May 2016Thumbnail for version as of 22:42, 7 May 2016442 × 432 (50 KB)Recitation-bot (talk | contribs)Automatic upload of media from: doi:10.1371/journal.pone.0027424

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